Comparison
Ketamine vs TMS
TMS (transcranial magnetic stimulation) is a non-invasive, non-medication option for depression. Ketamine is a pharmacological option with rapid effects.
Medically reviewed by: Pending medical review(draft)Last updated: June 4, 2026Evidence: Educational synthesis - not medical advice
Ketamine
TMS
Mechanism
NMDA-receptor antagonism and downstream plasticity.
Magnetic pulses stimulating cortical regions implicated in depression.
Evidence
Strong short-term TRD response data.
FDA-approved for depression; meaningful response and remission rates.
Onset
Hours to days.
Two to six weeks of daily sessions.
Duration
Days to weeks per session.
Often months after a completed course.
Side effects
Dissociation, BP changes, nausea.
Scalp discomfort, headache, rare seizure risk.
Access
Specialty clinics.
Specialty clinics, often insurance-covered.
Best for
Patients seeking rapid response or who have not tolerated medications.
Patients preferring a non-pharmacological, non-dissociative option who can commit to daily sessions.
Limits
Durability requires repeat dosing.
Time commitment for the initial course.
Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.