OCD and ketamine research
An overview of obsessive-compulsive disorder, gold-standard therapies, and where ketamine sits in the current evidence base.
Overview
Obsessive-compulsive disorder (OCD) involves intrusive thoughts (obsessions) and repetitive behaviors or mental acts (compulsions) used to reduce distress. OCD is treatable, but often underrecognized and undertreated.
Conventional treatment
Exposure and Response Prevention (ERP), a specialized form of CBT, is the leading evidence-based therapy for OCD. SSRIs are commonly used and often at higher doses than for depression.
Where ketamine fits
Small studies have explored ketamine in OCD, with mixed results. Evidence is not yet sufficient to consider ketamine a standard treatment.
What current evidence suggests
Current research suggests modest, short-term symptom reductions in some patients, but findings are inconsistent and trials are small.
Frequently asked questions
Is ERP still the best-supported treatment for OCD?+
Yes. Exposure and Response Prevention has the strongest evidence base for OCD and is typically recommended first.
Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.