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Protocols

KAP vs Infusion-Only: Two Models of Ketamine Care

The same molecule supports very different care models. KAP and medical-model infusion clinics serve overlapping but distinct patient needs.

Written by: Ira ZootMedically reviewed by: Ketalux Clinical Review PanelLast updated: June 4, 2026Evidence: Dore 2019; Drozdz 2022; clinical practice surveys
Quick answer
Which is right for me?
If your primary need is symptom relief from severe depression and you have access to ongoing therapy elsewhere, infusion-only can be appropriate. If you want to actively work with what surfaces — trauma, relational patterns, meaning — KAP is usually the better fit.

Side-by-side comparison

DimensionKAPInfusion-only
Primary clinicianTherapist + prescriberAnesthesiologist / psychiatrist
Typical modalitySublingual or IMIV
Session length2-3 hours45-60 minutes
Dose intentPsychedelic / experientialSub-psychedelic, antidepressant
FrequencyWeekly to monthly2-3x/week induction
Integration built inYesUsually no
Cost per session$400-$1,500$400-$800
InsuranceTherapy may bill; medication rarely coveredRarely covered (Spravato is exception)

What KAP adds

  • Pre-session preparation focused on intentions and history.
  • Therapist presence during the session for emotional safety.
  • Structured integration appointments after each medicine session.
  • Continuity of relationship across the arc of treatment.

What infusion-only adds

  • Faster, more reliable symptom relief for severe depression.
  • Medical oversight optimized for cardiovascular safety.
  • More efficient for patients who already have a strong therapist elsewhere.
About the author

Independent publisher and editor of Ketalux, based in Chicago, Illinois. Ira commissions, edits, and reviews every article on the site and believes ketamine therapy — used responsibly — offers real hope for people living with depression, anxiety, PTSD, and chronic pain. Contact: ira@idigits.com.

Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.