Protocols

Clinical Protocols: Dosing, Schedules & Treatment Models

Treatment design varies widely between clinics. These pages explain the dominant models so you can read a treatment plan critically and compare apples to apples.

Written by: Ira ZootMedically reviewed by: Ketalux Clinical Review PanelLast updated: June 4, 2026Evidence: Clinical literature & published protocol papers

Quick answer

Is there one standard protocol?

No. There is no universally agreed-upon protocol for ketamine in depression. Most clinics anchor on the original Yale/NIMH 6-infusion induction, then individualize maintenance. Variation is the norm — which is why understanding the menu matters.

Topics

Induction Series

The classic 6-infusion or 8-treatment loading phase: what it is and why.

Maintenance Dosing

Models for sustaining response: scheduled boosters vs symptom-triggered.

KAP vs Infusion-Only

Ketamine-assisted psychotherapy compared with medical-model infusions.

Combination Care

How ketamine pairs with SSRIs, therapy, TMS, and lifestyle medicine.

Dose Escalation

When and how clinicians titrate dose for non-responders.

Discontinuation & Taper

Knowing when to stop, slow down, or step away from ketamine treatment.

About the author

Ira Zoot

Independent publisher and editor of Ketalux, based in Chicago, Illinois. Ira commissions, edits, and reviews every article on the site and believes ketamine therapy — used responsibly — offers real hope for people living with depression, anxiety, PTSD, and chronic pain. Contact: ira@idigits.com.

Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.