2014 · RCT
Feder et al. 2014 - ketamine for PTSD
Efficacy of intravenous ketamine for treatment of chronic PTSD
Written by: Ira ZootMedically reviewed by: Ketalux Clinical Review PanelLast updated: June 4, 2026Evidence: Feder A et al.. JAMA Psychiatry, 2014.
Population
41 adults with chronic PTSD
Intervention
Single IV ketamine infusion
Comparator
Midazolam (active control)
Primary outcome
PTSD symptom severity
Key findings
- Significant reduction in PTSD symptoms within 24 hours
- Effect maintained over follow-up period
- First randomized evidence for ketamine in PTSD
Limitations
- Single dose
- Modest sample
- Short follow-up
Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.