mTOR pathway
A protein-kinase signaling pathway central to ketamine-induced plasticity.
This page has been written and edited by the publisher. It has not been reviewed by a licensed clinician.
Mechanistic target of rapamycin (mTOR) is a kinase complex that regulates protein synthesis at synapses. Ketamine transiently activates mTORC1 in the medial prefrontal cortex, driving synaptogenesis, spine formation, and the sustained antidepressant response observed after a single dose.
Related terms
- BDNF — Brain-derived neurotrophic factor - a growth factor for neurons.
- Synaptogenesis — The formation of new synaptic connections.
- Neuroplasticity — The brain's capacity to reorganize structure and function.
Definitions are educational and general. They are not medical advice.
Publisher and editor of Ketalux, based in Chicago, Illinois. Ira is a ketamine therapy patient, not a clinician. This is editorial review, not medical review: Ira is not a licensed clinician and does not provide diagnosis or medical care. Ketalux does not accept compensation from providers in exchange for favorable editorial coverage, evidence ratings, recommendations, patient referrals, or organic provider ranking. Read the full publisher disclosure →
Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.