AMPA Receptors & the Glutamate Surge
Block the dampers, and the excitatory circuits sing — at least for a few hours.
This page has been written and edited by the publisher. It has not been reviewed by a licensed clinician.
The cascade
- Ketamine blocks NMDA receptors on inhibitory interneurons.
- Excitatory neurons release a burst of glutamate.
- Glutamate activates AMPA receptors on neighboring neurons.
- AMPA activation triggers BDNF release and mTOR signaling.
- New synaptic proteins are synthesized within hours.
Clinical implication
The "antidepressant window" may correspond to the period when these new synaptic proteins are active. Why some people maintain effects for weeks while others fade in days is an open question — likely involving stress, sleep, and stimulation patterns during that window.
Publisher and editor of Ketalux, based in Chicago, Illinois. Ira is a ketamine therapy patient, not a clinician. This is editorial review, not medical review: Ira is not a licensed clinician and does not provide diagnosis or medical care. Ketalux does not accept compensation from providers in exchange for favorable editorial coverage, evidence ratings, recommendations, patient referrals, or organic provider ranking. Read the full publisher disclosure →
Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.