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Modalities

IV Ketamine Infusion

Most of the landmark depression trials used IV ketamine — it remains the comparator for everything else.

Written by: Ira ZootMedical review status: Not yet clinically reviewed.Last updated: June 4, 2026Evidence: Berman 2000, Zarate 2006, Wilkinson 2018 meta-analysis

This page has been written and edited by the publisher. It has not been reviewed by a licensed clinician.

Quick answer
What does an IV infusion look like?
A 40-minute infusion of 0.5 mg/kg racemic ketamine in saline, delivered in a reclining chair with continuous vital-sign monitoring. Effects begin within 5–10 minutes and resolve within ~90 minutes of infusion end.

Profile

  • Bioavailability: 100% (direct to bloodstream).
  • Onset: 5–10 minutes.
  • Duration of acute effects: 40–90 minutes.
  • Titration: real-time — clinician can slow or stop.
  • Setting: medical clinic with monitoring required.

Strengths

  • Deepest evidence base across depression, suicidality, and PTSD.
  • Most predictable dose-response relationship.
  • Highest safety in patients with cardiovascular risk (because of monitoring).

Trade-offs

  • Typically the highest per-session cost.
  • Not insurance-covered for depression (off-label).
  • Requires in-clinic time and a ride home.
Standard induction
Most protocols use 6 infusions over 2–3 weeks, followed by maintenance spacing based on response. There is no universal schedule.
About the author
Ira Zoot

Publisher and editor of Ketalux, based in Chicago, Illinois. Ira is a ketamine therapy patient, not a clinician. This is editorial review, not medical review: Ira is not a licensed clinician and does not provide diagnosis or medical care. Ketalux does not accept compensation from providers in exchange for favorable editorial coverage, evidence ratings, recommendations, patient referrals, or organic provider ranking. Read the full publisher disclosure →

Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.