Modalities
IV Ketamine Infusion
Most of the landmark depression trials used IV ketamine — it remains the comparator for everything else.
Medically reviewed by: Pending medical review(draft)Last updated: June 4, 2026Evidence: Berman 2000, Zarate 2006, Wilkinson 2018 meta-analysis
Profile
- Bioavailability: 100% (direct to bloodstream).
- Onset: 5–10 minutes.
- Duration of acute effects: 40–90 minutes.
- Titration: real-time — clinician can slow or stop.
- Setting: medical clinic with monitoring required.
Strengths
- Deepest evidence base across depression, suicidality, and PTSD.
- Most predictable dose-response relationship.
- Highest safety in patients with cardiovascular risk (because of monitoring).
Trade-offs
- Typically the highest per-session cost.
- Not insurance-covered for depression (off-label).
- Requires in-clinic time and a ride home.
Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.