Ketamine Routes of Administration
Different delivery routes produce different blood-level curves — and different experiences, costs, and safety profiles.
Compare each route
IV Infusion
The reference standard. 100% bioavailability, fully titratable, clinic-only.
Intramuscular (IM)
Single injection, ~93% bioavailable, less common but cost-effective.
Intranasal Esketamine (Spravato)
The only FDA-approved formulation, REMS-restricted clinic delivery.
Sublingual Troches & Lozenges
~30% bioavailable, often used in telehealth and KAP programs.
Oral Ketamine
Lowest bioavailability (~17%), longer-acting metabolites, niche use.
Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.