Modalities
Oral Ketamine
When ketamine is swallowed, first-pass metabolism produces high levels of norketamine — a different pharmacological footprint.
Medically reviewed by: Pending medical review(draft)Last updated: June 4, 2026Evidence: Synthesis of pharmacokinetic literature
Profile
- Bioavailability: ~17% (extensive first-pass metabolism).
- Onset: 30–60 minutes.
- Duration: longer-acting, gentler peak.
- Metabolite profile: high norketamine relative to other routes.
Strengths
- Simple administration; no special equipment.
- Smoother experience curve, less acute dissociation.
- Useful in chronic pain and palliative contexts.
Trade-offs
- Smallest evidence base for depression-specific outcomes.
- Variable absorption with food and gut motility.
- Take-home supply requires the same safeguards as sublingual.
Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.