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Neuroimaging & Brain Network Research

Imperial College London and ketamine research

Leading research on how ketamine and related compounds reshape brain activity and connectivity.

Written by: Ira ZootMedical review status: Not yet clinically reviewed.Last updated: May 18, 2026Evidence: Institutional research summary

This page has been written and edited by the publisher. It has not been reviewed by a licensed clinician.

Overview

Imperial College London's Centre for Psychedelic Research is internationally recognized for neuroimaging work showing how rapid-acting compounds modulate the default mode network and large-scale brain connectivity - providing a mechanistic window into how patients experience therapeutic effects.

Key contributions

  • Brain imaging studies during and after ketamine administration
  • Research on default mode network changes
  • Comparative neuroscience across rapid-acting compounds
  • Translational work linking brain dynamics to clinical outcomes

Selected studies

Default mode network connectivity following rapid-acting antidepressants

NeuroImage · 2020

fMRI evidence of altered network connectivity correlating with symptom improvement.

Visit the institution

Learn more directly from Imperial College London at https://www.imperial.ac.uk/psychedelic-research-centre/.

Location: London, United Kingdom. Studies listed here are representative and not exhaustive. For full literature, consult PubMed or the institution's own publications.

About the author

Publisher and editor of Ketalux, based in Chicago, Illinois. Ira is a ketamine therapy patient, not a clinician. This is editorial review, not medical review: Ira is not a licensed clinician and does not provide diagnosis or medical care. Ketalux does not accept compensation from providers in exchange for favorable editorial coverage, evidence ratings, recommendations, patient referrals, or organic provider ranking. Read the full publisher disclosure →

Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.