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Toolkit

Medication Review Checklist

This is a discussion guide — not a self-adjustment manual. Never stop or change medications without your prescriber.

Written by: Ira ZootMedical review status: Not yet clinically reviewed.Last updated: June 4, 2026Evidence: Educational patient decision aid

This page has been written and edited by the publisher. It has not been reviewed by a licensed clinician.

Quick answer
What's the highest-priority thing to disclose?
Every medication, supplement, and recreational substance — including cannabis, kratom, herbal sleep aids, and stimulants. Many interact with ketamine's effects or cardiovascular response.

Prepare a complete list

  • All prescription medications with doses and timing.
  • Over-the-counter medications used regularly.
  • Supplements, vitamins, and herbal products.
  • Recreational substances and frequency, honestly.
  • Recent antibiotics, antifungals, or grapefruit juice (CYP3A4 considerations).

Specific classes to ask about

  • Benzodiazepines: may blunt ketamine's antidepressant effect; some clinics adjust timing.
  • Lamotrigine: may reduce ketamine's dissociative and antidepressant effects.
  • Opioids: combined respiratory depression risk.
  • Stimulants: cardiovascular load consideration.
  • MAOIs: discuss carefully; hypertensive considerations.
  • Blood pressure medications: timing on session day.

Questions to ask

  • Should I take my morning meds on session day?
  • Are any of these likely to dampen ketamine's effects?
  • Any I should temporarily reduce, with your supervision?
  • Any supplements I should pause for safety?
  • How will we coordinate if you want to adjust anything?
Never adjust alone
Stopping psychiatric medications abruptly can cause discontinuation syndromes, rebound symptoms, or destabilization. Every change goes through your prescriber.
About the author

Publisher and editor of Ketalux, based in Chicago, Illinois. Ira is a ketamine therapy patient, not a clinician. This is editorial review, not medical review: Ira is not a licensed clinician and does not provide diagnosis or medical care. Ketalux does not accept compensation from providers in exchange for favorable editorial coverage, evidence ratings, recommendations, patient referrals, or organic provider ranking. Read the full publisher disclosure →

Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.