Glossary
Routes of administration
How ketamine is delivered: IV, IM, intranasal, sublingual, oral.
Medically reviewed by: Pending medical review(draft)Last updated: June 4, 2026Evidence: Educational definition
Clinical ketamine is delivered by intravenous infusion, intramuscular injection, intranasal spray (including esketamine), sublingual lozenges, or oral troches. Each route differs in bioavailability, onset, and clinical context.
Related terms
- Esketamine (Spravato) — FDA-approved S-enantiomer of ketamine, delivered intranasally.
- Racemic ketamine — The 50/50 mixture of R- and S-ketamine used off-label in most clinics.
Definitions are educational and general. They are not medical advice.
Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.