Glossary
Esketamine (Spravato)
FDA-approved S-enantiomer of ketamine, delivered intranasally.
Written by: Ira ZootMedically reviewed by: Ketalux Clinical Review PanelLast updated: June 4, 2026Evidence: Educational definition
Esketamine is the purified S-form of ketamine. It is FDA-approved for TRD and depression with acute suicidal ideation, administered in certified centers under REMS monitoring.
Related terms
- Treatment-resistant depression (TRD) — Depression that has not responded adequately to standard treatments.
- Racemic ketamine — The 50/50 mixture of R- and S-ketamine used off-label in most clinics.
Definitions are educational and general. They are not medical advice.
Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.