GABA
The brain's primary inhibitory neurotransmitter.
Gamma-aminobutyric acid (GABA) dampens neuronal firing. One proposed mechanism of ketamine's rapid effect is preferential blockade of NMDA receptors on GABAergic interneurons, producing a disinhibition-driven glutamate surge in pyramidal neurons.
Related terms
- Glutamate — The brain's primary excitatory neurotransmitter.
- NMDA receptor — A glutamate receptor central to ketamine's mechanism of action.
Definitions are educational and general. They are not medical advice.
Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.