NMDA receptor
A glutamate receptor central to ketamine's mechanism of action.
This page has been written and edited by the publisher. It has not been reviewed by a licensed clinician.
The N-methyl-D-aspartate (NMDA) receptor is a glutamate-gated ion channel involved in synaptic plasticity and memory. Ketamine acts as a non-competitive NMDA-receptor antagonist, transiently blocking the channel. Downstream effects include increased glutamate release, BDNF signaling, and synaptic remodeling.
Related terms
- Glutamate — The brain's primary excitatory neurotransmitter.
- BDNF — Brain-derived neurotrophic factor - a growth factor for neurons.
- Neuroplasticity — The brain's capacity to reorganize structure and function.
Definitions are educational and general. They are not medical advice.
Publisher and editor of Ketalux, based in Chicago, Illinois. Ira is a ketamine therapy patient, not a clinician. This is editorial review, not medical review: Ira is not a licensed clinician and does not provide diagnosis or medical care. Ketalux does not accept compensation from providers in exchange for favorable editorial coverage, evidence ratings, recommendations, patient referrals, or organic provider ranking. Read the full publisher disclosure →
Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.