Glutamate
The brain's primary excitatory neurotransmitter.
Glutamate carries the bulk of excitatory signaling in the central nervous system. Ketamine modulates glutamate signaling indirectly through NMDA-receptor blockade, producing a transient glutamate surge linked to its rapid antidepressant effects.
Related terms
- NMDA receptor — A glutamate receptor central to ketamine's mechanism of action.
- AMPA receptor — A glutamate receptor implicated in ketamine's downstream effects.
Definitions are educational and general. They are not medical advice.
Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.