Hydroxynorketamine (HNK)
A ketamine metabolite with antidepressant activity in preclinical models.
This page has been written and edited by the publisher. It has not been reviewed by a licensed clinician.
(2R,6R)-hydroxynorketamine is a downstream metabolite of ketamine. Preclinical studies show antidepressant-like effects independent of NMDA-receptor blockade, potentially via AMPA-receptor potentiation. Human evidence is still limited.
Related terms
- AMPA receptor — A glutamate receptor implicated in ketamine's downstream effects.
- NMDA receptor — A glutamate receptor central to ketamine's mechanism of action.
Definitions are educational and general. They are not medical advice.
Publisher and editor of Ketalux, based in Chicago, Illinois. Ira is a ketamine therapy patient, not a clinician. This is editorial review, not medical review: Ira is not a licensed clinician and does not provide diagnosis or medical care. Ketalux does not accept compensation from providers in exchange for favorable editorial coverage, evidence ratings, recommendations, patient referrals, or organic provider ranking. Read the full publisher disclosure →
Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.