Glossary
Off-label use
FDA-approved medications used for non-approved indications.
Written by: Ira ZootMedically reviewed by: Ketalux Clinical Review PanelLast updated: June 4, 2026Evidence: Educational definition
Racemic ketamine is FDA-approved as an anesthetic; its use for depression, anxiety, PTSD, OCD, and chronic pain is off-label. Off-label prescribing is legal and common in psychiatry but is not the same as unregulated.
Related terms
- Racemic ketamine — The 50/50 mixture of R- and S-ketamine used off-label in most clinics.
- Esketamine (Spravato) — FDA-approved S-enantiomer of ketamine, delivered intranasally.
Definitions are educational and general. They are not medical advice.
Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.