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Ketalux - Ketamine Therapy Education
Glossary

TrkB receptor

The primary receptor for BDNF signaling.

Written by: Ira ZootMedically reviewed by: Ketalux Clinical Review PanelLast updated: June 4, 2026Evidence: Educational definition

Tropomyosin receptor kinase B (TrkB) is activated by BDNF and triggers downstream cascades (PI3K–Akt–mTOR, MAPK) that support neuronal growth and synaptic plasticity. Emerging evidence suggests ketamine and its metabolites may bind TrkB directly, potentiating BDNF signaling.

Related terms

  • BDNF — Brain-derived neurotrophic factor - a growth factor for neurons.
  • mTOR pathway — A protein-kinase signaling pathway central to ketamine-induced plasticity.

Definitions are educational and general. They are not medical advice.

Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.