Safety Center
Potential Side Effects of Ketamine Therapy
Most side effects are transient and resolve within hours.
Medically reviewed by: Pending medical review(draft)Last updated: June 6, 2026Evidence: FDA esketamine labeling; clinical safety reviews
Common (most sessions)
- Dissociation during the active phase
- Transient BP / heart rate rise
- Mild nausea
- Dizziness or unsteadiness
- Post-session fatigue (2–6 hours)
Less common
- Headache
- Vivid dreams the night of
- Brief emotional reactivity in the 24–48 hours after
- Mild urinary urgency (rare in therapeutic dosing)
Rare / serious
- Severe BP elevation requiring intervention
- Prolonged dissociation or confusion
- Worsening mood or suicidal ideation
- Allergic reaction
Any of the rare events should prompt immediate clinic contact.
Related reading
Educational content only. Not medical advice. Discuss any treatment decisions with a qualified clinician.
Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.