Safety Center
Ketamine and Antidepressants
Most antidepressants are compatible with ketamine therapy \u2014 with a few exceptions worth knowing.
Medically reviewed by: Pending medical review(draft)Last updated: June 6, 2026Evidence: Clinical practice; published case literature
Common antidepressants and ketamine
- SSRIs / SNRIs — typically continued without modification.
- Bupropion — typically continued.
- Mirtazapine — typically continued.
- Lamotrigine — may blunt response; some clinicians adjust dose around session days.
- MAOIs — uncommon today; requires careful coordination because of BP interactions.
- Tricyclics — typically continued with cardiac monitoring.
What not to do
Do not stop antidepressants on your own to 'prepare' for ketamine. Abrupt discontinuation has its own risks.
Related reading
Educational content only. Not medical advice. Discuss any treatment decisions with a qualified clinician.
Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.