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Ketamine and Antidepressants

Most antidepressants are compatible with ketamine therapy \u2014 with a few exceptions worth knowing.

Written by: Ira ZootMedical review status: Not yet clinically reviewed.Last updated: June 6, 2026Evidence: Clinical practice; published case literature

This page has been written and edited by the publisher. It has not been reviewed by a licensed clinician.

Quick answer
Can I keep taking my antidepressants?
Most patients continue SSRIs, SNRIs, and atypical antidepressants throughout ketamine therapy. Lamotrigine has been associated with reduced ketamine response in some studies. MAOIs require specific clinical consideration. Always coordinate with the prescriber.

Common antidepressants and ketamine

  • SSRIs / SNRIs — typically continued without modification.
  • Bupropion — typically continued.
  • Mirtazapine — typically continued.
  • Lamotrigine — may blunt response; some clinicians adjust dose around session days.
  • MAOIs — uncommon today; requires careful coordination because of BP interactions.
  • Tricyclics — typically continued with cardiac monitoring.

What not to do

Do not stop antidepressants on your own to 'prepare' for ketamine. Abrupt discontinuation has its own risks.

Related reading

Educational content only. Not medical advice. Discuss any treatment decisions with a qualified clinician.

About the author
Ira Zoot

Publisher and editor of Ketalux, based in Chicago, Illinois. Ira is a ketamine therapy patient, not a clinician. This is editorial review, not medical review: Ira is not a licensed clinician and does not provide diagnosis or medical care. Ketalux does not accept compensation from providers in exchange for favorable editorial coverage, evidence ratings, recommendations, patient referrals, or organic provider ranking. Read the full publisher disclosure →

Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.