Ketamine and Benzodiazepines
Benzodiazepines can blunt ketamine's antidepressant effect.
This page has been written and edited by the publisher. It has not been reviewed by a licensed clinician.
Why it matters
Benzodiazepines act on GABA inhibitory signaling, which may dampen the glutamate surge thought to underlie ketamine's plasticity effects.
What clinicians often do
- Ask patients to skip the morning benzodiazepine dose on session day (when safe).
- Consider tapering long-term benzodiazepines, slowly, in coordination with the prescribing physician.
- Never advise abrupt discontinuation — benzodiazepine withdrawal can be dangerous.
Related reading
Educational content only. Not medical advice. Discuss any treatment decisions with a qualified clinician.
Publisher and editor of Ketalux, based in Chicago, Illinois. Ira is a ketamine therapy patient, not a clinician. This is editorial review, not medical review: Ira is not a licensed clinician and does not provide diagnosis or medical care. Ketalux does not accept compensation from providers in exchange for favorable editorial coverage, evidence ratings, recommendations, patient referrals, or organic provider ranking. Read the full publisher disclosure →
Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.