Ketalux - Ketamine Therapy EducationKetalux - Mental Wellness Authority
Safety Center

Ketamine and Benzodiazepines

Benzodiazepines can blunt ketamine's antidepressant effect.

Written by: Ira ZootMedically reviewed by: Ketalux Clinical Review PanelLast updated: June 6, 2026Evidence: Andrashko 2020; Albott 2017
Quick answer
Do benzodiazepines interfere with ketamine?
Multiple studies suggest concurrent benzodiazepine use is associated with diminished antidepressant response to ketamine. Many clinicians ask patients to hold benzodiazepines the day of session — never abruptly discontinue without medical guidance.

Why it matters

Benzodiazepines act on GABA inhibitory signaling, which may dampen the glutamate surge thought to underlie ketamine's plasticity effects.

What clinicians often do

  • Ask patients to skip the morning benzodiazepine dose on session day (when safe).
  • Consider tapering long-term benzodiazepines, slowly, in coordination with the prescribing physician.
  • Never advise abrupt discontinuation — benzodiazepine withdrawal can be dangerous.

Related reading

Educational content only. Not medical advice. Discuss any treatment decisions with a qualified clinician.

About the author
Ira Zoot

Independent publisher and editor of Ketalux, based in Chicago, Illinois. Ira commissions, edits, and reviews every article on the site and believes ketamine therapy — used responsibly — offers real hope for people living with depression, anxiety, PTSD, and chronic pain. Contact: ira@idigits.com.

Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.