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Safety Center

Ketamine and High Blood Pressure

Ketamine acutely raises blood pressure. Well-controlled hypertension is usually compatible; uncontrolled hypertension is not.

Written by: Ira ZootMedically reviewed by: Ketalux Clinical Review PanelLast updated: June 6, 2026Evidence: APA consensus 2017; FDA esketamine REMS
Quick answer
I have high blood pressure \u2014 can I still do ketamine?
If your blood pressure is well-controlled and you have no unstable cardiovascular disease, yes. Uncontrolled hypertension, recent stroke, or severe cardiovascular disease are typically exclusions. Pre-session and intra-session monitoring are standard.

What clinics monitor

  • Baseline BP and pulse at check-in.
  • BP every 10–15 minutes during the session.
  • Pre-defined thresholds for pausing or treating elevated BP.
  • Discharge after BP returns toward baseline.

Coordinate with your physicians

Bring a recent BP log. Continue your antihypertensive medications as prescribed unless your clinician advises otherwise.

Related reading

Educational content only. Not medical advice. Discuss any treatment decisions with a qualified clinician.

About the author
Ira Zoot

Independent publisher and editor of Ketalux, based in Chicago, Illinois. Ira commissions, edits, and reviews every article on the site and believes ketamine therapy — used responsibly — offers real hope for people living with depression, anxiety, PTSD, and chronic pain. Contact: ira@idigits.com.

Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.