Research Library
Clinical Trial Summaries — Ketamine Therapy
The trials that built the modern ketamine literature.
Medically reviewed by: Pending medical review(draft)Last updated: June 6, 2026Evidence: Berman 2000; Zarate 2006; Murrough 2013; Daly 2018
Foundational
- Berman 2000 — First small RCT showing rapid antidepressant response.
- Zarate 2006 — Replicated in TRD; established the rapid-onset profile.
- Murrough 2013 — Larger TRD sample; midazolam-controlled.
Esketamine pathway
- TRANSFORM-2 / TRANSFORM-3 — Acute efficacy.
- SUSTAIN-1 — Maintenance efficacy.
Beyond depression
- Feder et al. — Ketamine in PTSD.
- Rodriguez et al. — Ketamine in OCD.
- Wilkinson et al. — Ketamine and acute suicidal ideation.
Related reading
Educational content only. Not medical advice. Discuss any treatment decisions with a qualified clinician.
Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.