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For Loved Ones

Warning Signs to Watch For

You don't have to be a clinician to notice when something has shifted in a worrying direction.

Written by: Ira ZootMedical review status: Not yet clinically reviewed.Last updated: June 4, 2026Evidence: Educational guidance — not a substitute for medical advice

This page has been written and edited by the publisher. It has not been reviewed by a licensed clinician.

Quick answer
What's the threshold for raising concern?
Any change you'd want to know about if you were the clinician — major sleep disruption, withdrawal, hopelessness, escalating substance use, or talk of self-harm. Err on the side of mentioning it.

Subtle signs

  • Sleeping much more or much less than usual for 5+ days.
  • Withdrawal from people, food, or activities they normally enjoy.
  • Increased irritability, agitation, or emotional volatility.
  • Persistent dissociative symptoms outside of sessions.

Urgent signs

  • Talk of self-harm, hopelessness, or being a burden.
  • Giving away possessions or making sudden farewells.
  • Escalating substance use, especially alcohol or sedatives.
  • Hallucinations, paranoia, or marked personality change.
In a crisis
Call 988 (US Suicide & Crisis Lifeline), text HOME to 741741, or go to the nearest emergency room. If you're outside the US, find your local crisis line via findahelpline.com.
About the author

Publisher and editor of Ketalux, based in Chicago, Illinois. Ira is a ketamine therapy patient, not a clinician. This is editorial review, not medical review: Ira is not a licensed clinician and does not provide diagnosis or medical care. Ketalux does not accept compensation from providers in exchange for favorable editorial coverage, evidence ratings, recommendations, patient referrals, or organic provider ranking. Read the full publisher disclosure →

Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.