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Ketalux - Ketamine Therapy Education
Glossary

MADRS

Clinician-rated depression severity scale.

Written by: Ira ZootMedically reviewed by: Ketalux Clinical Review PanelLast updated: June 4, 2026Evidence: Educational definition

The Montgomery–Åsberg Depression Rating Scale is the outcome measure most commonly used in ketamine and esketamine trials. A ≥50% reduction from baseline defines treatment response in most protocols.

Related terms

  • PHQ-9 — A widely used self-report depression screening tool.

Definitions are educational and general. They are not medical advice.

Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.