Ketalux - Ketamine Therapy EducationKetalux - Mental Wellness Authority
2000 · RCT

Berman et al. 2000 - the first ketamine antidepressant RCT

Antidepressant effects of ketamine in depressed patients

Written by: Ira ZootMedical review status: Not yet clinically reviewed.Last updated: June 4, 2026Evidence: Berman RM et al.. Biological Psychiatry, 2000.

This page has been written and edited by the publisher. It has not been reviewed by a licensed clinician.

Quick answer
Why this study matters
The foundational study showing ketamine could produce antidepressant effects within hours rather than weeks - launching two decades of research.
Population
7 patients with major depression
Intervention
Single IV ketamine infusion (0.5 mg/kg over 40 min)
Comparator
Saline placebo
Primary outcome
Hamilton Depression Rating Scale change

Key findings

  • Significant reduction in depressive symptoms within 72 hours
  • Effect emerged within hours of infusion
  • Established proof-of-concept for rapid antidepressant action

Limitations

  • Very small sample
  • Short follow-up
  • Single dose

Read the original study →

Disclaimer
Educational summary only. A single study - even a landmark one - does not establish clinical practice. Discuss treatment decisions with a qualified clinician.
About the author
Ira Zoot

Publisher and editor of Ketalux, based in Chicago, Illinois. Ira is a ketamine therapy patient, not a clinician. This is editorial review, not medical review: Ira is not a licensed clinician and does not provide diagnosis or medical care. Ketalux does not accept compensation from providers in exchange for favorable editorial coverage, evidence ratings, recommendations, patient referrals, or organic provider ranking. Read the full publisher disclosure →

Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.