2000 · RCT
Berman et al. 2000 - the first ketamine antidepressant RCT
Antidepressant effects of ketamine in depressed patients
Medically reviewed by: Pending medical review(draft)Last updated: June 4, 2026Evidence: Berman RM et al.. Biological Psychiatry, 2000.
Population
7 patients with major depression
Intervention
Single IV ketamine infusion (0.5 mg/kg over 40 min)
Comparator
Saline placebo
Primary outcome
Hamilton Depression Rating Scale change
Key findings
- Significant reduction in depressive symptoms within 72 hours
- Effect emerged within hours of infusion
- Established proof-of-concept for rapid antidepressant action
Limitations
- Very small sample
- Short follow-up
- Single dose
Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.