Research Library

Ketamine Research in Chronic Pain

Ketamine has a parallel research history in chronic pain that predates the depression work.

Written by: Ira ZootMedically reviewed by: Ketalux Clinical Review PanelLast updated: June 6, 2026Evidence: AAPM/ASRA consensus on IV ketamine for chronic pain (2018)

Quick answer

Does ketamine help chronic pain?

Multiple controlled trials and consensus guidelines support sub-anesthetic ketamine infusions for complex regional pain syndrome and certain neuropathic pain conditions. Evidence in fibromyalgia, headache, and other syndromes is mixed.

Stronger evidence

Complex regional pain syndrome (CRPS)
Neuropathic pain refractory to standard treatments
Opioid-tolerant chronic pain (adjunct use)

Emerging / mixed

Fibromyalgia
Migraine and cluster headache
Phantom limb pain

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Educational content only. Not medical advice. Discuss any treatment decisions with a qualified clinician.

About the author

Ira Zoot

Independent publisher and editor of Ketalux, based in Chicago, Illinois. Ira commissions, edits, and reviews every article on the site and believes ketamine therapy — used responsibly — offers real hope for people living with depression, anxiety, PTSD, and chronic pain. Contact: ira@idigits.com.

Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.