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Research Library

Ketamine Research in Chronic Pain

Ketamine has a parallel research history in chronic pain that predates the depression work.

Written by: Ira ZootMedical review status: Not yet clinically reviewed.Last updated: June 6, 2026Evidence: AAPM/ASRA consensus on IV ketamine for chronic pain (2018)

This page has been written and edited by the publisher. It has not been reviewed by a licensed clinician.

Quick answer
Does ketamine help chronic pain?
Multiple controlled trials and consensus guidelines support sub-anesthetic ketamine infusions for complex regional pain syndrome and certain neuropathic pain conditions. Evidence in fibromyalgia, headache, and other syndromes is mixed.

Stronger evidence

  • Complex regional pain syndrome (CRPS)
  • Neuropathic pain refractory to standard treatments
  • Opioid-tolerant chronic pain (adjunct use)

Emerging / mixed

  • Fibromyalgia
  • Migraine and cluster headache
  • Phantom limb pain

Related reading

Educational content only. Not medical advice. Discuss any treatment decisions with a qualified clinician.

About the author

Publisher and editor of Ketalux, based in Chicago, Illinois. Ira is a ketamine therapy patient, not a clinician. This is editorial review, not medical review: Ira is not a licensed clinician and does not provide diagnosis or medical care. Ketalux does not accept compensation from providers in exchange for favorable editorial coverage, evidence ratings, recommendations, patient referrals, or organic provider ranking. Read the full publisher disclosure →

Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.