Glossary
Amygdala
A limbic structure central to fear and threat processing.
Written by: Ira ZootMedically reviewed by: Ketalux Clinical Review PanelLast updated: June 4, 2026Evidence: Educational definition
Amygdala hyperreactivity is associated with anxiety and PTSD. Ketamine acutely reduces amygdala reactivity to threat stimuli and may facilitate fear-memory reconsolidation, a mechanism relevant to trauma-focused protocols.
Related terms
- Prefrontal cortex (PFC) — The brain region most consistently implicated in ketamine's antidepressant action.
Definitions are educational and general. They are not medical advice.
Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.