This site demonstrates one possible use of this domain. For acquisition, partnership, or investment inquiries, please use our contact link.
Ketalux - Ketamine Therapy Education
Glossary

Default mode network (DMN)

A brain network active during self-referential thought.

Medically reviewed by: Pending medical review(draft)Last updated: June 4, 2026Evidence: Educational definition

The DMN is implicated in rumination, self-narrative, and mind-wandering. Hyperactivity of the DMN is associated with depression. Psychedelic-adjacent compounds, including ketamine at certain doses, transiently reduce DMN connectivity.

Related terms

  • Dissociation — A temporary altered sense of self, body, or surroundings.
  • Ego dissolution — A reduction in the felt sense of a bounded self.

Definitions are educational and general. They are not medical advice.

Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.