Glossary
Ego dissolution
A reduction in the felt sense of a bounded self.
Medically reviewed by: Pending medical review(draft)Last updated: June 4, 2026Evidence: Educational definition
Patients sometimes describe a softening of the usual self/other boundary during higher-dose ketamine sessions. The experience can be meaningful or destabilizing depending on set, setting, and integration.
Related terms
- Dissociation — A temporary altered sense of self, body, or surroundings.
- Default mode network (DMN) — A brain network active during self-referential thought.
Definitions are educational and general. They are not medical advice.
Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.