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Ketalux
PTSD & Veteran Mental Health

Icahn School of Medicine at Mount Sinai and ketamine research

Pioneering research on ketamine for PTSD, including some of the first randomized trials in this population.

Medically reviewed by: Pending medical review(draft)Last updated: May 18, 2026Evidence: Institutional research summary

Overview

Mount Sinai has produced some of the most influential clinical research on ketamine for post-traumatic stress disorder, including randomized controlled trials in veterans and civilians with chronic PTSD. Their program has shaped how the field thinks about rapid-acting interventions for trauma-related conditions.

Key contributions

  • First RCT of intravenous ketamine for chronic PTSD
  • Repeated-dose protocols for trauma-related symptoms
  • Research on durability of response and relapse prevention

Selected studies

Efficacy of intravenous ketamine for chronic PTSD

JAMA Psychiatry · 2014

Randomized controlled trial demonstrating significant reduction in PTSD symptoms 24 hours after infusion.

Visit the institution

Learn more directly from Mount Sinai at https://icahn.mssm.edu/.

Location: New York, New York, USA. Studies listed here are representative and not exhaustive. For full literature, consult PubMed or the institution's own publications.

Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.