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Ketalux - Ketamine Therapy Education
Glossary

Treatment-resistant depression (TRD)

Depression that has not responded adequately to standard treatments.

Medically reviewed by: Pending medical review(draft)Last updated: June 4, 2026Evidence: Educational definition

TRD is typically defined as failure to respond to at least two adequate trials of antidepressants. Ketamine and esketamine are most studied in this population.

Related terms

  • Esketamine (Spravato) — FDA-approved S-enantiomer of ketamine, delivered intranasally.
  • SSRI — Selective serotonin reuptake inhibitor - a class of antidepressants.

Definitions are educational and general. They are not medical advice.

Educational use only. The content on this page is provided for general educational purposes and does not constitute medical advice, diagnosis, or treatment. Ketamine and related therapies carry risks and are appropriate only under qualified medical supervision. Always consult a licensed healthcare professional about your individual situation. Information may change as research evolves.